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Statistics Seminar
September 12, 2025 | 11:00 am - 12:00 pm
Location: 2203 SAS Hall, NC State Main Campus
Speaker: Sarah Lotspeich
Assistant Professor
Department of Statistical Sciences
Wake Forest University
Title: Bridging statistics and bioinformatics to overcome data challenges in the learning health system
Abstract: Data from Electronic health records (EHR) present a huge opportunity to operationalize a standardized whole-person health score in the learning health system and identify at-risk patients on a large scale, except they are prone to missingness and errors. Ignoring these data quality issues could lead to biased statistical results and incorrect clinical decisions. Validation of EHR data (e.g., through chart reviews) can provide better-quality data. Still, realistically, only a subset of patients’ data can be validated, and most protocols do not recover missing data. Using a representative sample of 1000 patients from the EHR at an extensive learning health system (100 of whom could be validated), we bridge statistics and bioinformatics methods to design, conduct, and analyze statistically efficient and robust studies of the ALI and healthcare utilization. Employing semiparametric sieve maximum likelihood estimation, we robustly incorporate all available patient information into statistical models. Using targeted design strategies, we examine ways to select the most informative patients for validation. Incorporating clinical expertise, we devise a novel validation protocol to promote EHR data quality and completeness. Targeted validation with an enriched protocol allowed us to ensure the quality and promote the completeness of the EHR. Findings from our validation study were incorporated into statistical models, which indicated that worse whole-person health was associated with higher odds of engaging in the healthcare system, adjusting for age.